Hepatocellular carcinoma: From clinical practice to evidence-based treatment protocols

Adding to the evidence base: Effectiveness of hepatocellular carcinoma surveillance in clinical practice

Hepatocellular carcinoma (HCC) is the fifth most common solid cancer diagnosed globally and is the second leading cause of cancer mortality among adult males worldwide. In the United States, HCC is the fastest growing cause of cancer deaths. HCC incidence increased 3-fold between 1975 and 2009 and has had a recent plateauing of the trend. Despite advances in treatment, most HCC patients present...

evidence-based periodontology: from knowledge and attitude to practice

Pediatric anxiety disorders: from neuroscience to evidence-based clinical practice.

The objective of this narrative review of the literature is to describe the epidemiology, etiology, pathophysiology, diagnosis, and treatment of pediatric anxiety disorders. We aim to guide clinicians in understanding the biology of anxiety disorders and to provide general guidelines for the proper diagnoses and treatment of these conditions early in life. Anxiety disorders are prevalent, assoc...

Preclinical studies of 166Ho-chitosan for treatment of hepatocellular carcinoma

Introduction: Recently, due to the special characteristics of 166Ho and chitosan, 166Ho-chitosan complex was developed for treatment of tumors such as hepatocellular carcinoma. This complex has been lately prepared with high radiochemical purity in our lab. The preclinical studies of the complex however should be performed to evaluate the tracer concentration in target and...

Evidence-Based Clinical Practice

Evidence-based medicine has created a paradigm shift in medicine, away from authoritybased decision making and toward decision making that is informed by research and considers patient values and preferences. Evidence-based clinical practice requires accessing and evaluating the highest-quality information that is relevant to the patient problem at hand. In light of the best evidence, clinician...